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Pluripotency, Disease model and Tissue Regeneration
Our primary research focus revolves around deciphering the complex cellular signaling networks within pluripotent stem cells during early embryogenesis and stem cells through transient dedifferentiation during tissue injury. Our research utilizes state-of-the-art gene editing techniques to create disease model cells derived from human pluripotent stem cells and correct pathogenic mutations in patient-derived induced pluripotent stem cells (iPSCs). This comprehensive approach (disease in a dish) aims to investigate the molecular mechanisms underlying pathogenic phenotypes. Moreover, you employ advanced gene editing tools like base editors and prime editors to facilitate the functional recovery of genetic disease models derived from stem cells, both in vitro and in vivo. Our research endeavors hold the promise of providing critical insights into potential therapeutic strategies.
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