PUBLICATIONS (2018 - Present)
2026
Lee, S. S., Kim, Y.-J., Kang, S., Cha, H.-J. & Kim, H. U. Multi-omics analysis and metabolic modeling reveal BCL2L1-and CPT1A-driven fatty acid oxidation in culture-adapted human embryonic stem cells with implications for cell therapy safety. Chemical Engineering Journal, 174074, (2026).
Koo, K.-M. et al. Electrochemical platform for in situ metabolic profiling and therapeutic evaluation of triple-negative breast cancer. Chemical Engineering Journal, 173253, (2026).
Jo, B.-K., Song, Y. S., Song, W., Eom, H.-J., Lee, Y. J., Kim, J., Hong, S., Cho, S.-W. & Cha, H.-J. Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming. Cell Reports Medicine, in press (2026).
Kim, D.-W., Kwon, E.-J., Jeon, B.-J., Kwon, D.-H., Jang, G., Yoon, Y., Hwang, Y., Lee, H. & Cha, H.-J. Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids. Nature Communications, in press (2026).
Park, M. J., Kim, H.-B., Hwang, Y., Kim, Y.-J., Park, J.-C., Im, H.-K., Park, Y.-G., Moon, S., Lee, H. & Cha, H.-J. Patient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing. Experimental & Molecular Medicine, in press (2026).
Kim, DW., Kwon, EJ., Kwon, H., Kim, J. & Cha, HJ. Defective autophagy in GNE myopathy is rescued by inhibition of noncanonical Akt-mTORC1 activation across multiple isogenic models. Experimental & Molecular Medicine 1-16 (2026).
Eom, HJ., Jo, BK., Kim, J. & Cha, HJ. Oxidative Stress Drives Liver Failure During In Vivo Partial Reprogramming. Molecules and Cells 100378 (2026).
Kim, SM., Chu, YJ., et al. Mtf2 Safeguards Naïve Pluripotency by Restricting Trophectoderm Competence. Preprint (2026).
2025
Shin, Y.-Z. et al. Targeting HASPIN in gemcitabine-resistant pancreatic cancer cells by lead optimization of thioadenosine analogue. Biomedicine & Pharmacotherapy 188, 118135 (2025).
Park, S. et al. The protective role of GPX4 in naive ESCs is highlighted by induced ferroptosis resistance through GPX4 expression. Redox Biology 81, 103539 (2025).
Lee, S.-Y. et al. In silico chemical fingerprint screening identifies fisetin as a novel stemotoxic flavonoid. Biomedicine & Pharmacotherapy 190, 118369 (2025).
Kim, S.-M. et al. AMPK activation by glycogen expenditure primes the exit of naïve pluripotency. EMBO reports 26, 1504-1527 (2025).
Kim, K.-T., Kim, S.-M. & Cha, H.-J. Crosstalk between signaling pathways and energy metabolism in pluripotency. International journal of stem cells 18, 12-20 (2025).
Jo, BK., Lee, SY., Eom HJ. & Cha, HJ. Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming. Aging Cell 24, e70268 (2025).
2024
Park, J.-C. et al. Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways. nature communications 15, 4002 (2024).
Kwon, E.-J., Cha, H.-J. & Lee, H. Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors. Iscience 27 (2024).
Kim, Y.-J. et al. Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif. Biomedicine & Pharmacotherapy 176, 116758 (2024).
Kim, Y.-J. et al. Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis. Biomaterials Research 28, 0093 (2024).
Kim, Y.-J. et al. Longitudinal analysis of genetic and epigenetic changes in human pluripotent stem cells in the landscape of culture-induced abnormality. Experimental & Molecular Medicine, 1-14 (2024).
Kim, K.-T., Kim, S.-M. & Cha, H.-J. Crosstalk between signaling pathways and energy metabolism in pluripotency. International Journal of Stem Cells (2024).
Kim, J. et al. Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity. Cellular and Molecular Life Sciences 81, 38 (2024).
Eom, K.-h. et al. Mammalian ubiquitous promoter isolated from proximal regulatory region of bovine MSTN gene. Scientific Reports 14, 27750 (2024).
2023
Park, J.-C. et al. MutSα and MutSβ as size-dependent cellular determinants for prime editing in human embryonic stem cells. Molecular Therapy-Nucleic Acids, (2023).
Park, J.-C., Kim, K.-T., Jang, H.-K. & Cha, H.-J. Transition Substitution of Desired Bases in Human Pluripotent Stem Cells with Base Editors: A Step-by-Step Guide. International Journal of Stem Cells 16, 234, (2023).
Kwon, E.-J. & Cha, H.-J. Deep Learning Approach Based on Transcriptome Profile for Data Driven Drug Discovery. Molecules and Cells, 46, 65, (2023).
Koo, K.-M. et al. Label-free and non-destructive identification of naïve and primed embryonic stem cells based on differences in cellular metabolism. Biomaterials 293, 121939, (2023).
Kim, Y.-J. et al. TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells. Experimental & Molecular Medicine, 1-11, (2023).
Ho-Chang Jeong, et al. TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells with gain of 20q11.21. Stem Cell Review and Report, (2023).
Kwon EJ et al, In Silico Discovery of 5′-Modified 7-Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor. ACS Central Science 9 (6), 1140
Park JC et al, Gene editing with ‘pencil’rather than ‘scissors’ in human pluripotent stem cells. Stem Cell Research & Therapy 14 (1), 1-12
2022
Park, J.-C. et al. Multiple isogenic GNE-myopathy modeling with mutation specific phenotypes from human pluripotent stem cells by base editors. Biomaterials 282, 121419, (2022).
Park, J.-C. et al. High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells. Molecular Therapy-Nucleic Acids 27, 175-183, (2022).
Kim, S. Y. et al. The Korean undiagnosed diseases program phase I: expansion of the nationwide network and the development of long-term infrastructure. Orphanet Journal of Rare Diseases 17, 1-11, (2022).
Kim, S.-M. et al. Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells. Stem Cell Research & Therapy 13, 1-14, (2022).
Kim, K.-T. et al. Live isolation of naïve ESCs via distinct glucose metabolism and stored glycogen. Metabolic Engineering 72, 97-106, (2022).
Choi, S.-K. et al. Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations. Cellular Oncology 45, 913-930, (2022).
2021
Miasiro-Ciaramicoli, L., Seok-Kim, H. & Hyun-Yu, Y. Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library. RSC Chemical Biology 2, 1590-1593, (2021).
Kong, H. J. et al. Crosstalk between YAP and TGFβ regulates SERPINE1 expression in mesenchymal lung cancer cells. International Journal of Oncology 58, 111-121, (2021).
Hwang, S.-Y. et al. L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force. Nature communications 12, 880, (2021).
Choi, J. Y. et al. TGFβ promotes YAP‐dependent AXL induction in mesenchymal‐type lung cancer cells. Molecular Oncology 15, 679-696, (2021).
2020
Kwon, O.-S. et al. Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer. Oncogene 39, 4567-4580, (2020).
Kwon, O.-S. et al. ERK dephosphorylation through MKP1 deacetylation by SIRT1 attenuates RAS-driven tumorigenesis. Cancers 12, 909, (2020).
Kwon, O.-S. et al. Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis. Redox Biology 37, 101719, (2020).
Kim, K.-T. et al. Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance. Biomaterials 262, 120295, (2020).
Kim, D.-H. et al. Nuclear factor erythroid-derived 2-like 2-induced reductive stress favors self-renewal of breast cancer stem-like cells via the FoxO3a-Bmi-1 Axis. Antioxidants & Redox Signaling 32, 1313-1329, (2020).
Go, Y.-H. et al. Luteolin Induces Selective Cell Death of Human Pluripotent Stem Cells. Biomedicines 8, 453, (2020).
2019
Kwon, T., Kwon, O.-S., Cha, H.-J. & Sung, B. J. Stochastic and heterogeneous cancer cell migration: experiment and theory. Scientific reports 9, 1-13, (2019).
Kwon, O.-S., Kim, W., Cha, H.-J. & Lee, H. In silico drug repositioning: from large-scale transcriptome data to therapeutics. Archives of pharmacal research 42, 879-889, (2019).
Kaushik, N. et al. Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation. Cell Communication and Signaling 17, 1-13, (2019).
Go, Y.-H. et al. Structure-activity relationship analysis of YM155 for inducing selective cell death of human pluripotent stem cells. Frontiers in Chemistry 7, 298, (2019).
Bae, H., Go, Y.-H., Kwon, T., Sung, B. J. & Cha, H.-J. A theoretical model for the cell cycle and drug induced cell cycle arrest of FUCCI systems with cell-to-cell variation during mitosis. Pharmaceutical Research 36, 1-13, (2019).
2018
Yoon, D., Cha, H.-J., Lee, J.-S. & Chun, W. Enhancement of wound healing efficiency mediated by artificial dermis functionalized with EGF or NRG1. Biomedical Materials 13, 045007, (2018).
Seong, K. M. et al. Proactive strategy for long-term biological research aimed at low-dose radiation risk in Korea. International Journal of Radiation Biology 94, 685-693, (2018).
Kwon, O.-S. et al. In silico Drug Repositioning of bortezomib to reverse metastatic effect of GALNT14 in lung cancer. bioRxiv, 394163, (2018).
Kwon, O.-S. et al. Designing tyrosinase siRNAs by multiple prediction algorithms and evaluation of their anti-melanogenic effects. Biomolecules & Therapeutics 26, 282, (2018).
Kim, J. H. et al. Optimizing tissue-clearing conditions based on analysis of the critical factors affecting tissue-clearing procedures. Scientific reports 8, 12815, (2018).
Kim, D. J. et al. Covalent Functionalization of FeCo/Graphitic Shell Nanocrystals via 1, 3‐Dipolar Cycloaddition. ChemNanoMat 4, 132-139, (2018).
Im, J. H. et al. Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells. Science Bulletin 63, 477-487, (2018).
Hong, S.-K. et al. Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer. Molecular cancer 17, 1-7, (2018).
Go, Y.-H. et al. Screening of cytotoxic or cytostatic flavonoids with quantitative Fluorescent Ubiquitination-based Cell Cycle Indicator-based cell cycle assay. Royal Society open science 5, 181303, (2018).
Cui, Y.-H. et al. FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation. Oncogene 37, 5794-5809, (2018).
Cho, S.-J. et al. A fluorescent chemical probe CDy9 selectively stains and enables the isolation of live naive mouse embryonic stem cells. Biomaterials 180, 12-23, (2018).
Cho, S.-J. et al. Selective elimination of culture-adapted human embryonic stem cells with BH3 mimetics. Stem cell reports 11, 1244-1256, (2018).